Developmental Fluoride Neurotoxicity: Clinical Importance versus Statistical Significance

Developmental Fluoride Neurotoxicity: Clinical Importance versus Statistical Significance

We were interested to read the article by Choi et al. (2012), who investigated the effects of increased fluoride exposure and delayed neuro behavioral develop ment by reviewing published studies and performing a meta-analysis. Of the 39 studies identified, the authors considered 27 to be eligible. Choi et al. reported a mean difference in IQ (intelli gence quotient) score between exposed and re...

Developmental Fluoride Neurotoxicity: Choi et al. Respond

We were interested to read the article by Choi et al. (2012), who investigated the effects of increased fluoride exposure and delayed neuro behavioral develop ment by reviewing published studies and performing a meta-analysis. Of the 39 studies identified, the authors considered 27 to be eligible. Choi et al. reported a mean difference in IQ (intelli gence quotient) score between exposed and re...

Statistical Significance versus Clinical Significance in Clinical Trials

Developmental Fluoride Neurotoxicity: A Systematic Review and Meta-Analysis

BACKGROUND Although fluoride may cause neurotoxicity in animal models and acute fluoride poisoning causes neurotoxicity in adults, very little is known of its effects on children's neurodevelopment. OBJECTIVE We performed a systematic review and meta-analysis of published studies to investigate the effects of increased fluoride exposure and delayed neurobehavioral development. METHODS We se...

Statistical versus Practical Significance